Triglyceride-glucose index and risk of abdominal aortic aneurysm: a large-scale prospective cohort study

作者：Qiu-hong Tan, Zhiqiang Nie, Qiujin Huang, Yanchen Zhu, Chaolei Chen, Yingqing Feng · 发表于：Diabetology & Metabolic Syndrome · 年份：2025 · DOI：10.1186/s13098-025-01778-6 · 被引用次数：5 · 研究领域：Aortic aneurysm repair treatments、Aortic Thrombus and Embolism、Peripheral Artery Disease Management

Individuals with elevated triglyceride-glucose (TyG) index are prone to metabolic disturbances, which may accelerate the development of atherosclerotic diseases. While the relationship between TyG index and multiple cardiovascular diseases has been established, its association with incident abdominal aortic aneurysm (AAA) remains unclear. Therefore, this study aims to investigate the association between the TyG index and the risk of AAA. This prospective study included 428,382 participants with complete TyG index data and without aneurysms at baseline from the UK Biobank. The primary outcome was incident AAA. Multivariate Cox and restricted cubic spline (RCS) regression models were used to evaluate the association between TyG index and AAA. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. Additionally, sensitivity and subgroup analyses were performed to examine robustness of the results. During a median follow-up of 12.34 (IQR, 11.60-13.05) years, 2,153 (0.50%) new cases of AAA were identified. In adjusted models, an elevated TyG index was significantly linked to a higher risk of AAA, with an adjusted HR (95% CI) of 1.10 (1.05–1.16) per standard deviation (SD) increment. Compared to the lowest TyG quartile, the fully adjusted HRs for the second, third, and fourth quartiles were 1.21 (95% CI:1.04–1.42), 1.25 (95% CI:1.07–1.45), and 1.40 (95% CI:1.20–1.64), respectively. The RCS analysis revealed a linear relationship between the TyG index and the risk of...