Photocatalyzed 18 F-Fluorination: A Streamlined Radiolabeling Approach for Rapid Adoption and Automation

作者：Yueqi Wang, Lili Pan, Kai Lu, Mingxing Hu, Zheng Cheng, Mufeng Li, Yang Xie, Cheng Yang, Hongbao Sun, Xiaoai Wu, Haoxing Wu, Wei Chen · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c02193 · 被引用次数：10 · 研究领域：Fluorine in Organic Chemistry、Chemical Synthesis and Analysis、Click Chemistry and Applications

In this work, we established a simplified photoredox-mediated labeling system that allows the rapid aryl 18 F–fluorination of functional electron-neutral and electron-rich arenes via 19 F– 18 F exchange and/or deoxyfluorination without azeotropic drying, applying a HPO 4 2– preconditioned anion exchange resin. The labeling reaction can be performed with the whole eluted 18 F – other than a portion and has been verified on a radiosynthesis module. The simple reaction setup with all commercially available reagents and inexpensive equipment guarantees reproducibility and quick adoption.