Electrochemically driven direct C–H difluoroethylation of (hetero)arenes under metal/catalyst-free conditions

作者：Zheng LuPing, Yunfei Tian, Zhihui Gao, Jiayi Zhang, Jiahui Zhang, Jiajia Wang, Yuanfeng Liang, Weijun Fu, Zejiang Li · 发表于：Chemical Communications · 年份：2025 · DOI：10.1039/d5cc01983d · 被引用次数：7 · 研究领域：Fluorine in Organic Chemistry、Inorganic Fluorides and Related Compounds、Radical Photochemical Reactions

Me-substituted architectures. Notably, this electrochemical protocol successfully enabled the other valuable fluoroalkylation of heteroarenes. The controlled experiments indicated that a radical mechanism was involved in this transformation. The mild reaction conditions, excellent functional group compatibility, and good efficiency and selectivity render this method a promising strategy for late-stage modification of bioactive complex molecules.