Exercise training promotes nerve cell repair and regeneration after spinal cord injury

作者：Tianyu Zhai, Shuting Ren, Shenghao Qian, Caizhen Shi, Bingbing Wang, Can Zhang, Dan Li, Juan Shen, Feng Gao, Yanling Yang, Youlei Li, Lin Zhao · 发表于：Neural Regeneration Research · 年份：2025 · DOI：10.4103/nrr.nrr-d-24-01677 · 被引用次数：5 · 研究领域：Spinal Cord Injury Research、Nerve injury and regeneration、Neurogenesis and neuroplasticity mechanisms

Spinal cord injury is a severe neurological condition characterized by the permanent loss of nerve cell function and a failure in neural circuit reconstruction-key factors contributing to disability. Therefore, exploring effective strategies to promote the repair and regeneration of nerve cells after spinal cord injury is crucial for optimizing patient prognosis. The purpose of this paper is to conduct an in-depth review of the pathological changes in nerve cells after spinal cord injury and to present the state of research on the role of exercise training in promoting the repair and regeneration of nerve cells after spinal cord injury. In terms of the intrinsic growth capacity of neurons, disruptions in the dynamic balance between growth cones and the cytoskeleton, the dysregulation of transcription factors, abnormal protein signaling transduction, and altered epigenetic modifications collectively hinder axonal regeneration. Additionally, the microenvironment of neurons undergoes a series of complex changes, initially manifesting as edema, which may be exacerbated by spinal cord ischemia-reperfusion injury, further increasing the extent of nerve cell damage. The abnormal proliferation of astrocytes leads to the formation of glial scars, creating a physical barrier to nerve regeneration. The inflammatory response triggered by the excessive activation of microglia negatively impacts the process of nerve repair. Non-invasive interventions involving exercise training have shown ...