Fe‐Doped Carbon Dots Control the Biodegradation Behaviors of Zr‐Based Metal–Organic Framework for Tumor‐Specific Chemotherapy and Ferroptosis Enhanced Sono‐Chemodynamic Therapy

作者：Wenjing Shi, Chenqi Li, Nan Wang, Hongtao Lu, Gen Miao, Mengyu Cai, Jianxin Yang, Yinyin Zhang, Yicui Qu, Yuxiao Tang, Yizhou Wang, Hui Shen · 发表于：Small · 年份：2025 · DOI：10.1002/smll.202502028 · 被引用次数：16 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Nanoparticle-Based Drug Delivery

Zr-based metal-organic frameworks (Zr-MOF) with proper bandgap structure and excellent biocompatibility has recently been identified as a desired drug carrier and sonosensitizers for the application of drug delivery and sonodynamic therapy (SDT). However, the fast degradable behaviors of Zr-MOF not only in acidic tumor microenvironment (TME) but also in normal physiological conditions can lead to strong off-target toxicity. To realize tumor-specific drug release, herein, it reports for the first time the regulation of degradation behaviors of Zr-MOF using Fe-doped carbon dots (Fe-CDs) with excellent chemodynamic/sonodynamic activities as a protection layer. The obtained DOX/Zr-MOF/Fe-CDs possesses TME-responsive degradation feature, which avoids the degradation of Zr-MOF under normal physiological conditions. In addition, the deposition of Fe-CDs not only improves the sonodynamic activity of Zr-MOF owing to the formation of Z-scheme heterojunctions, but also endows the novel nanoplatform with excellent chemodynamic activity. After completing SDT process, DOX/Zr-MOF/Fe-CDs can respond to acidic TME to specifically degrade and release Fe-CDs and DOX, which thereby triggered tumor-specific ferroptosis and chemotherapy. Significantly, the single treatment of DOX/Zr-MOF/Fe-CDs successfully eradicates tumors through tumor-specific chemotherapy and ferroptosis amplified SDT/CDT. This work presents an innovative strategy for the regulation of degradation behaviors of nanocarriers to ...