Efficacy of Mesenchymal Stem Cells in the Treatment of Diabetic Foot Ulcers: A Meta-Analysis of Randomized Controlled Trials

作者：X. Mei, Tong Zhang, Yanhui Yang, Li Sun, Rui‐Min Han, Na Wu, Ye Tian, B. Li, Min Ge, Defeng Wang · 发表于：The International Journal of Lower Extremity Wounds · 年份：2025 · DOI：10.1177/15347346251348797 · 被引用次数：5 · 研究领域：Diabetic Foot Ulcer Assessment and Management、Wound Healing and Treatments、Mesenchymal stem cell research

Background Diabetic foot ulcers (DFUs), a severe chronic complication of diabetes, are characterized by refractory wounds and high risks of amputation/mortality, posing substantial public health challenges. Mesenchymal stem cells (MSCs) demonstrate therapeutic potential through synergistic mechanisms including paracrine signaling, immunomodulation, neovascularization, and tissue regeneration. This study conducts a systematic review and meta-analysis of randomized controlled trials (RCTs) to comprehensively evaluate the clinical efficacy of MSC-based therapy for DFUs, aiming to optimize treatment strategies with evidence-based insights. Method We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for RCTs investigating MSC therapy in DFUs. Following PRISMA guidelines, studies were selected with pre-defined criteria. Meta-analyses employed random-/fixed-effects models based on I 2 statistics. Primary endpoints encompassed complete healing rate (100% epithelialization), amputation incidence, serious adverse events (SAEs) risk, and recurrence rate. Furthermore, sensitivity analyses were conducted to evaluate the robustness of the findings. A comprehensive assessment of potential publication bias in the current meta-analysis was performed using Egger's linear regression test, Begg's rank correlation test, and funnel plot visualization. Results Six RCTs were included. MSC therapy significantly improved overall complete healing rates (RR = 1.63, 95% CI: 1.2...