Framework for Brain-Derived Dimensions of Psychopathology

作者：Tristram A. Lett, Nilakshi Vaidya, Tianye Jia, Elli Polemiti, Tobias Banaschewski, Arun L.W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie‐Laure Paillère Martinot, Éric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Hervé Lemaître, Tomáš Paus, Luise Poustka, Argyris Stringaris, Lea Waller, Zuo Zhang, Jeanne Winterer, Yuning Zhang, Michael N. Smolka, Robert Whelan, Ulrike Schmidt, Julia Sinclair, Henrik Walter, Jianfeng Feng, Trevor W. Robbins, Sylvane Desrivières, André F. Marquand, Gunter Schumann, Gunter Schumann, Esther Hitchen, Elli Polemiti, Hedi Kebir, Tristram A. Lett, Nilakshi Vaidya, Jean-Charles Roy, Henrik Walter, Andreas Heinz, Markus Ralser, Sven Twardziok, Emin Serin, Roland Eils, Marcel Jentsch, Ulrike Taron, Tatjana Schütz, Kerstin Schepanski, Tobias Banaschewski, Maja Neidhart, Andreas Meyer‐Lindenberg, Heike Tost, Nathalie Holz, Emanuel Schwarz, Argyris Stringaris, Nina Christmann, Karina Janson, Frauke Nees, Beke Seefried, Rieke Aden, Ole A. Andreassen, Lars T. Westlye, Dennis van der Meer, Sara Fernández‐Cabello, Rikka Kjelkenes, Helga Ask, Michael A. Rapp, Mira Tschorn, Sarah Jane Böttger, André F. Marquand, Antoine Bernas, Gaia Novarino, Mel Slater, Jaime Gallego, Álvaro Pastor, Guillem Feixas, Francisco José Eiroá‐Orosa, Markus M. Nöthen, Andreas J. Forstner, Isabelle Claus, Carina M. Mathey, Stefanie Heilmann‐Heimbach, Per Hoffmann, Abigail Miller, Peter Sommer, Karen M. Schmitt, Johannes Wilbertz, Myrto Patraskaki, Viktor Jirsa, Spase Petkoski, Anastasios Athanasiadis, Bernhard Spanlang, Charlie Pearmund, Sören Hese, Paul Renner, Tianye Jia, Xiao Chang, Jiacan Yuan, Yuxiang Dai, Yunman Xia, Yuzhu Li, Yanqing Zhang, Vince D. Calhoun, Paul M. Thompson, Nicholas Clinton, Sylvane Desrivières, Kofoworola Agunbiade, Xinyang Yu, Zuo Zhang, Di Chen, Allan H. Young, Ameli Schwalber, Vanessa Köhler, Bernd Carsten Stahl, George Ogoh, Tamara Schikowski, Ragnhild Eek Brandlistuen · 发表于：JAMA Psychiatry · 年份：2025 · DOI：10.1001/jamapsychiatry.2025.1246 · 被引用次数：9 · 研究领域：Mental Health Research Topics、Functional Brain Connectivity Studies、Digital Mental Health Interventions

Importance: Psychiatric diagnoses are not defined by neurobiological measures hindering the development of therapies targeting mechanisms underlying mental illness. Research confined to diagnostic boundaries yields heterogeneous biological results, whereas transdiagnostic studies often investigate individual symptoms in isolation. Objective: To develop a framework that groups clinical symptoms compatible with ICD-10 and DSM-5 according to their covariation and shared brain mechanisms. Design, Setting, and Participants: This diagnostic study was conducted in 2 samples, the population-based Reinforcement-Related Behaviour in Normal Brain Function and Psychopathology (IMAGEN) cohort (longitudinal assessments at 14, 19, and 23 years; study duration from March 2010 to the present) and the cross-diagnostic Brain Network Based Stratification of Mental Illness (STRATIFY)/Earlier Detection and Stratification of Eating Disorders and Comorbid Mental Illnesses (ESTRA) samples (study duration from October 2016 to September 2023). The samples are from 8 clinical research hospitals in Germany, the UK, France, and Ireland. For the population-based IMAGEN study, 794 of 1253 23-year-old participants had complete assessments including complete clinical assessments and neuroimaging data across all time points. For the cross-diagnostic STRATIFY/ESTRA samples, 209 of 485 participants aged 18 to 26 years had complete clinical and neuroimaging data. The sample included healthy control individuals an...