Intermittent fasting for weight loss in night shift workers: a three-arm, superiority randomised clinical trial

作者：Maxine P. Bonham, Gloria K. W. Leung, Michelle Rogers, Rochelle Davis, Angela B. Clark, Corinne Davis, Yan Yin Phoi, Robert S. Ware, Asmaa El‐Heneidy, Nicole J. Kellow, Jillian Dorrian, Siobhan Banks, Tracey L. Sletten, Catherine E. Huggins, Alison M. Coates · 发表于：EBioMedicine · 年份：2025 · DOI：10.1016/j.ebiom.2025.105803 · 被引用次数：8 · 研究领域：Dietary Effects on Health、Muscle metabolism and nutrition、Circadian rhythm and melatonin

BACKGROUND: Weight gain and an increased risk of developing type 2 diabetes are recognised consequences of night shift work. We tested the effectiveness of two modified intermittent fasting (IF) strategies compared with continuous energy restriction (CER) on weight loss and improvements in insulin resistance in night shift workers. METHODS: A parallel group, three-arm randomised superiority clinical trial (Melbourne and Adelaide) recruited night shift workers (aged ≥ 25 and ≤ 65 years) with overweight/obesity. Participants were randomised by minimisation (site, age, gender) 1:1:1 to CER or one of two modified IF strategies. For 24 weeks participants followed a diet of 2100 kJ/d for two days of the week (modified IF) either on days off/day shift (IF:2D) or whilst on night shift (IF:2N) and followed their usual diet on the remaining five days. Co-primary outcomes were body weight and insulin resistance measured by the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) at 24-weeks. Participants and those assessing weight outcomes were not blinded to group assignment. Researchers assessing biochemical outcomes and study statistician were blinded to group assignment. Between-group differences were calculated using mixed-effects regression models. FINDINGS: From October 2019 to February 2022, 250 participants (CER = 85; IF:2D = 83; IF:2N = 82) were randomised (mean (SD) age 46.8 (9.8) years; 133 women (53.2%)), with 170 (68%) completing. No significant difference between...