The impacts of long-term carbon disulfide exposure on glucose homeostasis and type 2 diabetes: a multifaceted gene-environment-lifestyle interaction study of Chinese adults

作者：Yueru Yang, Jiahao Song, Yongfang Zhang, Shuhui Wan, Zhi-Ying Huo, Qing Liu, Le Huynh Thi Cam Hong, Linling Yu, Wei Liu, Ruyi Liang, Bin Wang, Weihong Chen · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2025.06.039 · 被引用次数：11 · 研究领域：Carcinogens and Genotoxicity Assessment、Air Quality and Health Impacts、Health, Environment, Cognitive Aging

• Long-term CS 2 exposure impaired glucose homeostasis and increased T2D risk. • Gene-CS 2 -lifestyle interactions on glucose dyshomeostasis and T2D were identified. • High genetic risk aggravated CS 2 -related glucose dyshomeostasis and T2D risk. • Healthy lifestyle alleviated CS 2 -related glucose dyshomeostasis and T2D risk. • Reduce CS 2 and improve lifestyle help to prevent T2D especially for those at high genetic risk. The long-term impacts of exposure to carbon disulfide (CS 2 ), a highly concerning air toxicant listed by the Clean Air Act, and its interactions with genetic susceptibility and lifestyle on glucose homeostasis and type 2 diabetes (T2D) in the general population remain unclear and require urgent clarification. To investigate the interactions of CS 2 exposure, genetic susceptibility, and lifestyle on glucose homeostasis and T2D. In this prospective study, urinary CS 2 metabolite (2-Thiothiazolidine-4-carboxylic acid, TTCA) and fasting plasma glucose (FPG) and insulin (FPI) for 5294 observations from 2523 participants were repeatedly measured to examine the cross-sectional and longitudinal associations of CS 2 exposure with glucose homeostasis and T2D by performing generalized linear mixed models or COX models. Polygenic risk score (PRS) and healthy lifestyle index (HLI) were constructed to evaluate their cross-sectional and longitudinal interactions with TTCA and to assess gene-CS 2 -lifestyle interactions. TTCA was cross-sectionally and longitudinally rel...