A dual-component particulate dressing for simultaneous microenvironment modulation and tissue regeneration in infected diabetic wounds

作者：Jianwei Li, Mengkun Wang, Xiang‐Mei Tan, Yingxi Duanmiao, Xiang Zheng, Zhen Wang, Fei Gao, Yuqing Miao, Huipeng Li, Bo Liu, Mingjun Li, Tingbin Zhang, Huan Zhou, Jinfeng Xing, Lei Yang · 发表于：Materials Today Bio · 年份：2025 · DOI：10.1016/j.mtbio.2025.102005 · 被引用次数：9 · 研究领域：Wound Healing and Treatments、Diabetic Foot Ulcer Assessment and Management、Pressure Ulcer Prevention and Management

The treatment of chronic diabetic wounds faces considerable challenges owing to complex environments in the wound bed, such as chronic inflammation, excessive reactive oxygen species (ROS), impaired extracellular matrix (ECM) and bacterial infection. Current strategies, including bandages, hydrogel dressings and medical devices, that focus solely on a few pathological features have limited success. Herein, a fast self-gelling polyacrylic acid (PAA) derivative/madecassoside (MA) particulate dressing with anti-inflammatory, antioxidative, collagen deposition-promoting and intrinsic antibacterial properties is developed to simultaneously regulate the wound microenvironment and promote tissue regeneration in infected diabetic wounds. The incorporation of N-[Tris(hydroxymethyl)methyl]acrylamides (THMA), a small molecule compound that has three hydroxy groups clustered together, into the PAA backbone confers the copolymer with self-gelation, robust wet tissue adhesion and a strong capacity to load MA via multiple hydrogen bonding. The developed dual-component particulate dressing effectively regulated macrophage polarization towards the anti-inflammatory phenotype, and showed superior killing ratio for both Gram-positive S. aureus (99.2%) and Gram-negative E. coli (90.8%) at a concentration of 8 mg mL -1 . Further, the dressing obviously accelerated the healing of full-thickness skin wounds compared with commercial fibrin glue in a S. aureus -infected diabetic mouse model. This mul...