Steam-exploded Dictyophora indusiata polysaccharide protect against inflammation by regulating gut barrier, microbiota and metabolites

作者：Zhi-Kun Zeng, Lin Wang, Zihao Zhang, Ya-Qing Lin, Bin Xiong, Baodong Zheng, Yi Zhang, Lei Pan · 发表于：Food & medicine homology. · 年份：2025 · DOI：10.26599/fmh.2026.9420107 · 被引用次数：9 · 研究领域：Gut microbiota and health、Ginger and Zingiberaceae research、Fungal Biology and Applications

The present study aimed to investigate the effects of steam-exploded Dictyophora indusiata polysaccharide (DIPS) on lipopolysaccharide (LPS)-induced inflammation of mice. The results showed that DIPS significantly improved colonic shortening by LPS-induced inflammation, and the mRNA expression of Occludin ( Occ ) and Zonula occludens-1 ( ZO-1 ) in colon tissues was increased 9.86- and 2.69-fold after DIPS intervention, respectively. In addition, DAI scores decreased from 1.15 to 0.74, while the mRNA expression of pro-inflammatory cytokines tumor necrosis factor-α ( TNF-α ) and interleukin-6 ( IL-6 ) were also reduced by DIPS intervention. It is remarkable that DIPS modulated the composition of gut microbiota and enhanced the relative abundance of Bifidobacterium , unclassified_o_ Oscillospirales and Faecalibaculum . Furthermore, the levels of acetic acid and propionic acid of the gut contents in mice were restored to (0.94 ± 0.24) mg/g and (0.23 ± 0.10) mg/g after the intervention of DIPS, which was 3.03- and 2.56-fold of the LPS group, respectively. In conclusion, DIPS protected against LPS-induced inflammation, which provides new insights into the anti-inflammatory effect of edible fungi polysaccharide.