Psychosocial stressors and cognitive function: An analysis using data from the English longitudinal study of ageing

作者：Jiahao Li, Natalia Ortí-Casañ, Irem Bayraktaroglu, Giulia Mozzanica, Feng Zhang, Berend Olivier, Ulrich Eisel · 发表于：The Journal of Prevention of Alzheimer s Disease · 年份：2025 · DOI：10.1016/j.tjpad.2025.100232 · 被引用次数：6 · 研究领域：Dementia and Cognitive Impairment Research、Aging and Gerontology Research、Health disparities and outcomes

BACKGROUND: Growing evidence suggests that psychosocial stressors-such as financial strain, caregiving responsibilities, disability, and limiting long-term illnesses-may contribute to accelerated cognitive decline in older adults. However, the heterogeneity of stressor profiles and their distinct impact on specific cognitive domains remain poorly understood. OBJECTIVE: To examine the associations between varying burdens of psychosocial stressors and cognitive function over a 10-year period using data from the English Longitudinal Study of Ageing (ELSA). METHODS: We used longitudinal data from wave 4 (2008-2009) to wave 9 (2018-2019) of ELSA, comprising 10,893 participants aged ≥50 years at baseline who had valid measurements of psychosocial stressors and cognitive outcomes. Psychosocial stressors-financial strain, caregiving, disability, and limiting long-term illness-were assessed as binary indicators and summed into three categories (No Stressors, One Stressor, Multiple Stressors). Cognitive function was assessed using an overall global cognition score and scores of three specific domains: memory, executive function, and orientation. Baseline associations were examined via multiple linear regression, while linear mixed-effects models evaluated longitudinal trajectories of cognitive change. All models were progressively adjusted for demographic, lifestyle, and clinical covariates. RESULTS: At baseline, participants reporting multiple stressors (18.2 % of the sample) had sign...