The American Society for Microbiology’s evidence-based laboratory medicine practice guidelines for the diagnosis of bloodstream infections using rapid tests: a systematic review and meta-analysis

作者：Donna M. Wolk, J. Scott Parrott, N. Esther Babady, A. Brian Mochon, Ryan J. Tom, Christen Diel, Jennifer Dien Bard, Amanda Harrington, D. Jane Hata, Amity L. Roberts, Lindsay Boyce, J. Kristie Johnson · 发表于：Clinical Microbiology Reviews · 年份：2025 · DOI：10.1128/cmr.00137-24 · 被引用次数：33 · 研究领域：Bacterial Identification and Susceptibility Testing、Streptococcal Infections and Treatments、Meta-analysis and systematic reviews

SUMMARYBloodstream infections (BSIs) are a significant cause of mortality and morbidity. Rapid identification of pathogens and detection of a few resistance markers from positive blood cultures are now possible through the increased availability of commercial rapid diagnostic tests, including nucleic acid amplification tests and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. This document describes the clinical utility of rapid diagnostics performed on positive blood cultures and provides evidence-based laboratory medicine guidelines for using rapid tests to diagnose BSIs in hospitalized adult and pediatric patients. This guideline was developed for use by medical (a.k.a. clinical) microbiologists, medical laboratory professionals, infectious disease clinicians, pharmacists, hospital administrators, healthcare providers, and other stakeholders associated with BSIs. A panel of experts, including medical microbiologists and experts in systematic literature review, was assembled to formulate the Population-Intervention-Comparison-Outcome (PICO) question, review the literature, and provide recommendations for using rapid tests to diagnose BSI and improve patient outcomes. A comprehensive literature search of four electronic bibliographic databases (MEDLINE, Embase, CINAHL, and Cochrane) was conducted to identify studies with measurable outcomes. The panel followed a systematic process, which included a standardized methodology for rating the certain...