Photoinduced EDA Complexes Enabled C(sp 2 )–OMe Bond Cleavage and Cyanation of Electron-Rich Arenes

作者：Jun Zhou, Sijia Zhang, Wenjie Liu, Jiaxin Yang, Xi Du, Siping Wei, Xia Zhou, Anping Luo, Bowen Lei · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c01967 · 被引用次数：3 · 研究领域：Radical Photochemical Reactions、Oxidative Organic Chemistry Reactions、Catalytic C–H Functionalization Methods

)-OMe bond cleavage and cyanation was established by using 1,4-dicyanobenzene as both an electron-deficient acceptor and a low-toxicity cyanide source. Mechanistic studies revealed the role of double EDA complexes in forming the cyanide anion and aromatic cation radical intermediate, leading to a diverse array of valuable aryl nitrile derivatives in good to excellent yields. Furthermore, late-stage functionalization of biorelevant compounds and gram-scale synthesis demonstrate the utility of this methodology.