Association of maternal overweight and gestational diabetes mellitus with offspring adiposity trajectory: from birth to early adolescence

作者：Yuzhi Deng, Claudia H.T. Tam, Aimin Yang, Mai Shi, Lai Yuk Yuen, Noel Ng, Atta Y T Tsang, Kit Ying Tsoi, Risa Ozaki, Albert Martin Li, Elaine Chow, Lai Ling Hui, Juliana C.N. Chan, Chi Chiu Wang, Wing Hung Tam, Ronald C.W. · 发表于：Diabetologia · 年份：2025 · DOI：10.1007/s00125-025-06468-6 · 被引用次数：8 · 研究领域：Gestational Diabetes Research and Management、Diabetes, Cardiovascular Risks, and Lipoproteins、Obesity, Physical Activity, Diet

AIMS/HYPOTHESIS: We aimed to examine offspring adiposity trajectories from birth to age 9-14 years and to assess the joint associations of maternal overweight and gestational diabetes mellitus (GDM) with these trajectories. METHODS: This is a prospective cohort study with 564 mother-child dyads from the Hyperglycemia and Adverse Pregnancy Outcome study Hong Kong field centre. Assessments and anthropometric measurements were taken during pregnancy, at delivery and at median ages of 7 and 10 years postpartum. Offspring adiposity was primarily assessed using sum of skinfold thickness. We used linear mixed-effect models to evaluate the independent and joint associations of maternal overweight and GDM with the offspring adiposity trajectories, and applied group-based trajectory modelling to identify distinct patterns of adiposity development based on both statistical indices and clinical interpretability. RESULTS: Offspring skinfold thickness trajectories varied significantly based on maternal overweight and GDM (p<0.05). Group-based trajectory modelling identified two trajectory groups for skinfold thickness: 52.1% with slow increase and 47.9% with rapid increase. Combined maternal overweight and GDM was associated with 6.90-fold increased risk (95% CI 1.89, 33.32; p=0.006) of the rapidly increasing trajectory. Linear mixed-effect model analysis showed greater increases in skinfold thickness among offspring of mothers with either condition, with the highest trajectory observed in...