Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity

作者：Alexis Moscoso, Fiona Heeman, Sheelakumari Raghavan, Alejandro Costoya‐Sánchez, Martijn van Essen, Ismini Mainta, Valle Camacho, Omar Darío Rodríguez-Fonseca, Jesús Silva‐Rodríguez, Andrés Perissinotti, Yuna Gu, Jihwan Yun, Débora Elisa Peretti, Federica Ribaldi, Emma M. Coomans, Wagner S. Brum, Michel J. Grothe, Pablo Aguiar, Gérard N. Bischof, Alexander Drzezga, Sang Won Seo, Sylvia Villeneuve, Maura Malpetti, John T. O’Brien, James B. Rowe, Elsmarieke van de Giessen, Rik Ossenkoppele, William Jagust, Ruben Smith, Oskar Hansson, Giovanni B. Frisoni, Valentina Garibotto, David N. Soleimani‐Meigooni, Marı́a C. Carrillo, Bradford C. Dickerson, Renaud La Joie, Gil D. Rabinovici, Liana G. Apostolova, Pamela LaMontagne, Michael J. Pontecorvo, Keith A. Johnson, Reisa A. Sperling, Michael W. Weiner, Ronald C. Petersen, Clifford R. Jack, Prashanthi Vemuri, Michael Schöll, Angela Tam, Anne Labonté, Alexa Pichet Binette, Anne‐Marie Faubert, Axel Mathieu, Cécile Madjar, Charles Edouard Carrier, Christian Dansereau, Christina Kazazian, Claude Lepage, Cynthia Picard, David Maillet, Diane Michaud, Doris Couture, Doris Dea, A. Claudio Cuello, Alan Barkun, Alan C. Evans, Blandine Courcot, Christine Tardif, Clément Debacker, David Fontaine, David S. Knopman, Gerhard Multhaup, Jamie Near, Jeannie‐Marie Leoutsakos, Jean‐Robert Maltais, Jason Brandt, Jens C. Pruessner, John C. Morris, John C.S. Breitner, Judes Poirier, Laksanun Cheewakriengkrai, D. Louis Collins, M. Mallar Chakravarty, Mark A. Sager, Marina Dauar‐Tedeschi, Mark J. Eisenberg, Natasha Rajah, Paul Aisen, Paule‐Joanne Toussaint, Pedro Rosa‐Neto, Bellec Pierre, Penelope Kostopoulos, Pierre Étienne, Pierre N. Tariot, Pierre Orban, Rick Hoge, Ronald J. Thomas, Serge Gauthier, Suzanne Craft, Thomas J. Montine, Vasavan Nair, Véronique D. Bohbot, Vinod Venugopalan, Vladimir Fonov, Yasser Ituria‐Medina, Zaven S. Khachaturian, Eduard Teigner, Elena Anthal, Elsa Yu, Fabiola Ferdinand, Galina Pogossova, Ginette Mayrand, Guerda Duclair, Guylaine Gagné, Holly Newbold‐Fox, Illana Leppert, Isabelle Vallée, Jacob W. Vogel, Jennifer Tremblay‐Mercier, Joanne Frenette, Josée Frappier, Justin Kat, Justin Miron, Karen Wan, Laura Mahar, Leopoldina Carmo, Louise Théroux, Mahsa Dadar, Marianne Dufour, Marie‐Élyse Lafaille‐Magnan, Melissa Appleby, Mélissa Savard, Miranda Tuwaig, Mirela Petkova, Pierre Rioux, P.T. Meyer, Rana El‐Khoury, Renee Gordon, Renuka Giles, Samir Das, Seqian Wang, Shirin Tabrizi, Sulantha Mathotaarachchi, Sylvie Dubuc, Tanya Lee, Thomas Beaudry, Valérie Gervais, Véronique Pagé, Julie Gonneaud, Tharick A. Pascoal, René Desautels, Fatiha Benbouhoud, Eunice Farah Saint‐Fort, Sander C.J. Verfaillie, Sarah Farzin, Alyssa Salaciak, Stéphanie Tullo, Étienne Vachon‐Presseau, Leslie‐Ann Daoust, Theresa Köbe, R. Nathan Spreng, Melissa McSweeney, Nathalie Nilsson, Morteza Pishnamazi, Christophe Bedetti, Louise Hudon, Claudia Greco, Marianne Chapleau, Frédéric St‐Onge, Sophie Boutin, Maiya R. Geddes, Simon Ducharme, Gabriel Jean, Elisabeth Sylvain, Marie‐Josee Élie, Gloria Leblond‐Baccichet, Jean‐Paul Soucy, Hazal Ozlen, Julie Bailly, Béry Mohammediyan, Yalin Chen, Jordana Remz, Dorene M. Rentz, Rebecca E. Amariglio, Deborah Blacker, Rachel F. Buckley, Jasmeer P. Chhatwal, Brad C. Dickerson, Nancy J. Donovan, Michelle E. Farrell, Geoffroy Gagliardi, Jennifer R. Gatchel, Edmarie Guzmán‐Vélez, Heidi I.L. Jacobs, Roos J. Jutten, Cristina Lois Gómez, Gad A. Marshall, Kate Oaoo, Enmanuelle Pardilla‐Delgado, Julie Price, Prokopis C. Prokopiou, Yakeel T. Quiroz, Gretchen Reynolds, Aaron P. Schultz, Stephanie A. Schultz, Jorge Sepulcre, Irina A. Skylar-Scott, Patrizia Vannini, Clara Vila‐Castelar, Hyun‐Sik Yang, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C Green, Andrew J. Saykin, John C. Morris, Richard J. Perrin, Leslie M. Shaw, William Z. Potter, Lisa L. Barnes, Marie Bernard, Héctor Alfredo Baptista González, Carole Ho, John Hsiao, Jonathan Jackson, Eliezer Masliah, Donna Masterman, Ozioma Okonkwo, Laurie Ryan, Nina Silverberg, Adam Fleisher, Juliet Fockler, Cat Conti, Dallas P. Veitch, John Neuhaus, Chengshi Jin, Rachel L. Nosheny, Mariam Ashford, Derek Flenniken, Adrienne Kormos, Tom Montine, Michael Rafii, Rema Raman, Gustavo Jimenez‐Maggiora, Michael Donohue, Devon Gessert, Jennifer Salazar, Caileigh Zimmerman, Yuliana Cabrera, Sarah Walter, Garrett Miller, Godfrey Coker, Taylor Clanton, Lindsey Hergesheimer, Stephanie Smith, Olusegun Adegoke, Payam Mahboubi, Shelley Moore, Jeremy Pizzola, Elizabeth Shaffer, Danielle Harvey, Arvin Forghanian-Arani, Bret Borowski, Chad Ward, Christopher G. Schwarz, David T. Jones, Jeff Gunter, Kejal Kantarci, Matthew L. Senjem, Robert I. Reid, Nick C. Fox, Ian B. Malone, Paul Thompson, Sophia I. Thomopoulos, Talia M. Nir, Neda Jahanshad, Charles DeCarli, Alexander Knaack, Evan Fletcher, Duygu Tosun, Stephanie R Chen, Mark Choe, Karen Crawford, Paul A Yuschkevich, Sandhitsu R. Das, Robert A. Koeppe, Eric M. Reiman, Kewei Chen, Chet Mathis, Susan Landau, Nigel J. Cairns, Erin Householder, Erin Franklin, Haley Bernhardt, Lisa Taylor‐Reinwald, Magdalena Korecka, Michal Figurski, Scott Neu, Kwangsik Nho, Shannon L. Risacher, Li Shen, Tatiana M. Foroud, Kelly Nudelman, Kelley Faber, Kristi Wilmes, Leon J. Thal, Jeffrey L. Dage, Ani Eloyan, Tatiana M. Foroud, Bernardino Ghetti, Lea T. Grinberg, Dustin B. Hammers, Kala Kirby, Joel Kramer, Robert A. Koeppe, Walter A. Kukull, Julien Legarde, Melissa E. Murray, Kathy L. Newell, Angelina J. Polsinelli, Alexander Taurone, Maryanne Thangarajah, Arthur W. Toga, Alexandra Touroutoglou, Alireza Atri, David Clark, Gregory S Day, Ranjan Duara, Neill R Graff-Radford, Ian Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik S. Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalskı, Steven Salloway, Sharon J. Sha, Raymond Scott Turner, Thomas S. Wingo, S. J. Wolk, Kyle Womack · 发表于：JAMA · 年份：2025 · DOI：10.1001/jama.2025.7817 · 被引用次数：56 · 研究领域：Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments、Intracerebral and Subarachnoid Hemorrhage Research

Importance: Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD). Objective: To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes. Design, Setting, and Participants: Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample of 6514 participants from 13 countries, collected between January 2013 and June 2024. Cognitively unimpaired individuals and patients with a clinical diagnosis of mild cognitive impairment (MCI), AD dementia, or other neurodegenerative disorders were included. Exposures: Tau PET with flortaucipir F 18, amyloid-β (Aβ) PET, and clinical examinations. Tau PET scans were visually rated as positive according to a US Food and Drug Administration- and European Medicines Agency-approved method, designed to indicate the presence of advanced neurofibrillary tangle pathology (Braak stages V-VI). Main Outcomes and Measures: Frequency of tau PET positivity and absolute risk of clinical progression (eg, progression to MCI or dementia). Results: Among the 6514 participants (mean age, 69.5 years; 50.5% female), median follow-up time ranged from 1.5 to 4.0 years. Of 3487 cognitively unimpaired participants, 349 (9.8%) were tau PET positive; the estimated frequency of tau PET positivity was less than 1% in those aged younger than 50 years, and increased from 3% (95% CI, 2%-4%) at 60 years to 19% (95% ...