Public Water Arsenic and Birth Outcomes in the Environmental Influences on Child Health Outcomes Cohort

作者：Anne E. Nigra, Tessa R. Bloomquist, Tushara Rajeev, Mohamad Burjak, Joan A. Casey, Dana E. Goin, Julie B. Herbstman, Yoshira Ornelas Van Horne, Blair J. Wylie, Ilan Cerna-Turoff, Joseph M. Braun, Kristen McArthur, Margaret R. Karagas, Jennifer Ames, Allison R. Sherris, Catherine M. Bulka, Amy Padula, Caitlin G. Howe, Rebecca C. Fry, Lauren A. Eaves, Carrie V. Breton, Andrea E. Cassidy‐Bushrow, Johnnye Lewis, Debra MacKenzie, Daniel Beene, Shohreh F. Farzan, Sheela Sathyanarayana, Alison E. Hipwell, Rachel Morello‐Frosch, Brittney M. Snyder, Tina V. Hartert, Amy J. Elliott, Thomas O’Connor, Amii Kress, P. Brian Smith, L. Kristin Newby, Linda S. Adair, Lisa P. Jacobson, Diane Catellier, Monica McGrath, Christian Douglas, Priya Duggal, Emily A. Knapp, Amii Kress, Courtney K. Blackwell, Maxwell Mansolf, Jin‐Shei Lai, Emily Ho, David Cella, Richard Gershon, Michelle L. Macy, Suman R. Das, Jane E. Freedman, S. Mallal, John A. McLean, Ravi V. Shah, Meghan H. Shilts, Akram N. Alshawabkeh, José F. Cordero, John Meeker, Leonardo Trasande, Carlos A. Camargo, Kohei Hasegawa, Zhaozhong Zhu, Ashley F. Sullivan, Dana Dabelea, Wei Perng, Traci A. Bekelman, Greta Wilkening, Sheryl Magzamen, Brianna F. Moore, Anne P. Starling, Deborah Rinehart, Daphne Koinis Mitchell, Viren D’Sa, Sean Deoni, Hans-Georg Mueller, Cristiane S. Duarte, Catherine Monk, Glorisa Canino, Jonathan Posner, Tenneill Murray, Claudia Lugo‐Candelas, Anne L. Dunlop, Patricia A. Brennan, Christine W. Hockett, Amy J. Elliott, Assiamira Ferrara, Lisa Croen, Monique M. Hedderson, John Ainsworth, Leonard B. Bacharier, Casper G. Bendixsen, James E. Gern, Diane R. Gold, Tina V. Hartert, Daniel J. Jackson, Christine Cole Johnson, Christine L.M. Joseph, Meyer Kattan, Gurjit K. Khurana Hershey, Robert F. Lemanske, Susan V. Lynch, Rachel Miller, George O'connor, Carole Ober, Dennis R. Ownby, Katherine Rivera‐Spoljaric, Patrick Ryan, Christine M. Seroogy, Anne Marie Singh, R.J.K. Wood, Edward M. Zoratti, Rima Habre, Shohreh F. Farzan, Frank D. Gilliland, Irva Hertz‐Picciotto, Deborah H. Bennett, Julie B. Schweitzer, Rebecca J. Schmidt, Janine M. LaSalle, Alison E. Hipwell, Catherine J. Karr, Nicole R. Bush, Kaja Z. LeWinn, Sheela Sathyanarayana, Qi Zhao, Frances A. Tylavsky, Kecia N. Carroll, Christine T. Loftus, Leslie D. Leve, Jody M. Ganiban, Jenae M. Neiderhiser, Scott T. Weiss, Augusto A. Litonjua, Cindy T. McEvoy, Eliot R. Spindel, Robert S. Tepper, Craig J. Newschaffer, Kristen Lyall, Heather E. Volk, Rebecca Landa, Sally Ozonoff, Joseph Piven, Heather C. Hazlett, Juhi Pandey, Robert T. Schultz, Steven Dager, Kelly N. Botteron, Daniel S. Messinger, Wendy L. Stone, Jennifer Ames, Thomas O’Connor, Richard K. Miller, Emily Oken, Michele R. Hacker, Tamarra James‐Todd, T. Michael O’Shea, Rebecca C. Fry, Jean A. Frazier, Rachana Singh, Caitlin Rollins, Angela Montgomery, Ruben Vaidya, Robert M. Joseph, Lisa K. Washburn, Semsa Gogcu, Kelly Bear, Julie V. Rollins, Stephen R. Hooper, Genevieve Taylor, Wesley Jackson, Amanda L. Thompson, Julie L. Daniels, Michelle Hernandez, Kun Lu, Michael E. Msall, Madeleine Lenski, Rawad Obeid, Steven L. Pastyrnak, Elizabeth T. Jensen, Christina Sakai, Hudson P. Santos, Jean M. Kerver, Nigel Paneth, Charles Barone, Michael R. Elliott, Douglas M. Ruden, Chris Fussman, Julie B. Herbstman, Amy Margolis, Susan L. Schantz, Sarah Dee Geiger, Andréa Sílvia Walter de Aguiar, Karen M. Tabb, Rita S. Strakovsky, Tracey J. Woodruff, Rachel Morello‐Frosch, Amy Padula, Joseph B. Stanford, Christina A. Porucznik, Angelo P. Giardino, Rosalind J. Wright, Robert O. Wright, Brent R. Collett, Nicole Baumann-Blackmore, Ronald E. Gangnon, Chris McKennan, Jo Wilson, Matt Altman, Judy L. Aschner, Annemarie Stroustrup, Stephanie L. Merhar, Paul E. Moore, Gloria Pryhuber, Mark L. Hudak, Ann Marie Reynolds Lyndaker, Andrea Lampland, Burton Rochelson, Sophie Jan, Matthew J. Blitz, Michelle Katzow, Zenobia Brown, Codruța Chiuzan, Timothy J. Rafael, Dawnette Lewis, Natalie Meirowitz, Brenda B. Poindexter, Tebeb Gebretsadik, Sarah S. Osmundson, Jennifer K. Straughen, Amy Eapen, Andrea E. Cassidy‐Bushrow, Ganesa Wegienka, Alex Sitarik, Kim Woodcroft, Audrey Urquhart, Albert M. Levin, Tisa Johnson-Hooper, Brent Davidson, Tengfei Ma, Emily S. Barrett, Martin J. Blaser, Maria Gloria Domínguez-Bello, Daniel B. Horton, Manuel Jiménez, Todd Rosen, Kristy Palomares, Lyndsay A. Avalos, Yeyi Zhu, Kelly J . Hunt, Roger Newman, Michael S. Bloom, Mallory Alkis, James R. Roberts, Sunni L. Mumford, Heather H. Burris, Sara B. DeMauro, Lynn M. Yee, Aaron Hamvas, Antonia F. Olidipo, Andrew Haddad, Lisa R. Eiland, Nicole T. Spillane, Kirin Suri, Stephanie A. Fisher, Jeffrey A. Goldstein, Leena B. Mithal, Raye‐Ann deRegnier, Nathalie L. Maitre, Ruby H.N. Nguyen, Meghan M. JaKa, Abbey Sidebottom, Michael J. Paidas, JoNell Potter, Natale Ruby, Lunthita Duthely, Arumugam R. Jayakumar, Karen Young, Isabel Maldonado, Meghan Miller, Jonathan L. Slaughter, Sarah A. Keim, Courtney D. Lynch, Kartik K. Venkatesh, Kristina W. Whitworth, Elaine Symanski, Thomas F. Northrup, Hector Mendez‐Figueroa, Ricardo A. Mosquera, Margaret R. Karagas, Juliette C. Madan, Debra M. MacKenzie, Johnnye Lewis, Brandon Rennie, Bennett Leventhal, Young S. Kim, Somer Bishop, Sara S. Nozadi, Li Luo, Barry M. Lester, Carmen J. Marsit, Todd M. Everson, Cynthia M. Loncar, Elisabeth C. McGowan, Stephen J. Sheinkopf, Brian S. Carter, Jennifer Check, Jennifer Helderman, Charles R. Neal, Lynne M. Smith · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.14084 · 被引用次数：5 · 研究领域：Arsenic contamination and mitigation、Heavy Metal Exposure and Toxicity、Carbon and Quantum Dots Applications

Importance: Inorganic arsenic is associated with adverse birth outcomes, but evidence is limited for public water concentrations (modifiable by federal regulatory action) in US populations. Objective: To evaluate the association between prenatal public water arsenic exposure below the federal regulatory standard of 10 μg/L and birth outcomes in the US. Design, Setting, and Participants: This cohort study analyzed observational pregnancy cohort data from the Environmental Influences on Child Health Outcomes (ECHO) Cohort for birthing parent-infant dyads from 35 pregnancy cohort sites. Infants were born between 2005 and 2020. The data were analyzed between 2024 and 2025. Exposure: Individual, time-weighted, mean prenatal public water arsenic exposures were estimated by joining Zip Code Tabulation Area-level public water arsenic concentrations with monthly residential history data during pregnancy. Main Outcome and Measure: Adjusted risk ratios (RRs) of preterm birth, low birth weight, and small for gestational age were evaluated. Adjusted RRs, mean differences in birth weight-for-gestational age z score and birth weight, and the geometric mean ratio of gestational age at birth were calculated via cubic splines, per 1 μg/L higher prenatal water arsenic, and across policy-relevant categories of exposure. Results: The cohort comprised 13 998 birthing parents (mean [SD] age, 30.8 [5.6] years) of whom 4.5% were of American Indian, Alaska Native, Native Hawaiian, or Pacific Islander;...