Lactate trajectories and outcomes in patients with sepsis in the intensive care unit: group-based trajectory modeling

作者：Wei Yu, Jinqiang Zhuang, Jiaqi Li, Zixuan Wang, Jing Wang, Xiaojie Zhang, Junling Leng · 发表于：Frontiers in Public Health · 年份：2025 · DOI：10.3389/fpubh.2025.1610220 · 被引用次数：12 · 研究领域：Sepsis Diagnosis and Treatment、Immune Response and Inflammation、Bacterial Identification and Susceptibility Testing

Background: Sepsis is highly heterogeneous. Therefore, identifying biomarkers that can stratify patients with sepsis into more homogeneous cohorts to develop individualized treatment and care measures for patients and carry out early intervention to reduce the risk of death and improve the prognosis of patients has become a current research hotspot. Methods: Using the MIMIC-IV database, we analyzed data from 1,575 adult patients with sepsis. Serum lactate levels were measured once daily for 5 consecutive days after admission. The GBTM model was used to stratify the risk of sepsis and explore the relationships between different lactate trajectories and 28-day mortality in septic patients. Results: We report a new method for identifying subphenotypes of sepsis patients based on lactate trajectories. Through group-based trajectory modeling, we identified and validated five groups of sepsis patients with different lactate trajectories, namely, "Low-stable group," "low-slowly declining group," "high-rapidly decline group," "Moderate-slow declining group," and "high-slow decline group." The relationships between sepsis patients with different lactate trajectories and 28-day mortality were explored. Among them, patients with a "Low-stable group" had the lowest in-hospital 28-day mortality. Patients with a "high-slow decline group" had the highest 28-day mortality. Conclusion: In this study, different subtypes of sepsis were successfully identified by analyzing lactate trajectories. ...