Low-fibre diet is associated with high-risk coronary plaque features

作者：Ingrid Larsson, Jiangming Sun, Shafqat Ahmad, Göran Bergström, Carl‐Johan Carlhäll, Kerstin Cederlund, Isabel Drake, Jan Engvall, Mats Eriksson, Henrik Hagström, Tomas Jernberg, Tanja Kero, Krister Lindmark, Maria Mannila, Marju Orho‐Melander, Araz Rawshani, Ulf Risérus, Annika Rosengren, Mats Ryberg, Caroline Schmidt, Emily Sonestedt, Maria Wennberg, Carl Johan Östgren, Isabel Gonçalves · 发表于：Cardiovascular Research · 年份：2025 · DOI：10.1093/cvr/cvaf088 · 被引用次数：6 · 研究领域：Nutritional Studies and Diet、Agriculture Sustainability and Environmental Impact、Food composition and properties

AIMS: Diet is a determinant of cardiovascular diseases (CVD) with coronary disease as predominant cause of pre-mature death. To analyse how diet was associated with coronary atherosclerosis, including plaque features. METHODS AND RESULTS: The cross-sectional population-based study using data from the Swedish CArdioPulmonary BioImage Study (SCAPIS) included 24 079 adults aged 50-64 years, recruited in 2013 to 2018 who were free of clinical cardiovascular disease. The recruitment and comprehensive examinations were conducted at six locations in Sweden. A dietary index (DI) based on a previously published anti-inflammatory DI including high proportion of plant-based foods, and low in red or processed meat and sugar-sweetened beverages was constructed. The reference group was within lowest DI tertile. Coronary atherosclerosis assessed by coronary computed tomography angiography, including any-, significant-, and adverse or high-risk coronary plaque, which is non-calcified with a significant stenosis ≥50%. Lowest, compared to highest DI tertile was associated with younger age, more often men (62.2% vs. 32.9%), higher high-sensitive C-reactive protein, more cardiometabolic risk and smokers, higher alcohol-, and higher energy-intake. In the highest and lowest tertile, coronary plaques were present in 36.3% and 44.3%, respectively, stenosis ≥ 50% in 3.7% and 6.0%. Non-calcified coronary plaques with stenosis ≥50% were present in 0.9% and 1.5% in highest and lowest tertiles. In multiv...