The Effectiveness of Cryotherapy or Compression Therapy in Preventing Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Network Meta-Analysis

作者：Hao Chen, Koji Hashiguchi, Muhammad Habibullah Khan, Bhaumik Shah · 发表于：Journal of Clinical Question · 年份：2025 · DOI：10.69854/jcq.2025.0014 · 被引用次数：3 · 研究领域：Cancer Treatment and Pharmacology、Management of metastatic bone disease、Pain Mechanisms and Treatments

Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting adverse effect of neurotoxic chemotherapy agents. Despite its prevalence and clinical significance, effective preventive strategies are limited. Cryo- and compression therapy have emerged as promising non-pharmacological interventions. Methods: A comprehensive literature search was performed across PubMed, Embase, Cochrane Library, and Web of Science up to March 31, 2025. Eligible studies included randomized controlled trials and self-controlled trials assessing the preventive efficacy of cryotherapy-related interventions in adult cancer patients undergoing neurotoxic chemotherapy. The primary outcome was the incidence of CIPN. A frequentist random-effects network meta-analysis was conducted to estimate odds ratios (ORs). Results: A total of 13 studies involving 865 patients were included in the analysis. Cryotherapy was found to be associated with a significant reduction in CIPN incidence compared to usual care (OR: 0.32, 95% CI: 0.17–0.60), followed by compression therapy (OR: 0.44, 95% CI: 0.21–0.94). Among the specific modalities evaluated, continuous cooling (OR: 0.25, 95% CI: 0.07–0.93) and frozen gloves (OR: 0.28, 95% CI: 0.12–0.68) showed the highest preventive efficacy. The surface under the cumulative ranking curve (SUCRA) values supported these findings, with cryotherapy ranked as the most effective intervention overall (SUCRA = 0.873), particularly continuous cooling (0.734)...