Trends and projections of heart failure among adolescents and young adults: an in-depth analysis for the Global Burden of Disease Study 2021

作者：Songren Shu, Zhiwei Zeng, Yicheng Yang, Huan Wang, Bo Sun, Pugazhenthan Thangaraju, Hao Cui, Mengxia Fu, Sher Zaman Safi, Peizhi Wang, Chuangshi Wang, Zarrin Basharat, Ziang Yang, Mohammad Fayaz, Jianhui Yuan, Zhanhao Su, Qiaoxi Yang, Huimin Gao, T.F. Yang, Changming Xiong, Guyu Zeng, Weizhuang Yuan, Zhiming Peng, Zhiling Luo, Wenjie Yan, Yanbing Ma, Jing Xu, Zhiyong Zou, Yuan Huang, Jiangping Song · 发表于：European Heart Journal - Quality of Care and Clinical Outcomes · 年份：2025 · DOI：10.1093/ehjqcco/qcaf040 · 被引用次数：6 · 研究领域：Heart Failure Treatment and Management、Cardiomyopathy and Myosin Studies、Cardiovascular Function and Risk Factors

AIMS: The prevalence of heart failure (HF) continues to rise with a growing impact on younger populations, while epidemiological comprehensive data on HF in adolescents and young adults remain scarce. This study aimed to report population shifts and HF burden among individuals aged 15-49 years from 1990 to 2021, with projections through 2035. METHODS AND RESULTS: Data were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 for individuals aged 15-49 years. We investigated the population shift and analysed the temporal trend in HF prevalence and years lived with disability (YLDs) from 1990 to 2021 using the estimated annual percentage change (EAPC) and age-period-cohort (APC) model. We also assessed the underlying causes of HF and examined the associations between Sociodemographic Index (SDI) and the prevalence and YLDs of HF using Pearson correlation. Finally, the Bayesian age-period-cohort (BAPC) model was employed to project HF burdens through 2035. Between 1990 and 2021, global HF prevalence among individuals aged 15-49 years increased by 76.76% (95% uncertainty interval: 71.02, 83.33), with the most substantial growth observed in the African region (2.67-fold), Eastern Mediterranean region (2.63-fold), and South-East Asia region (2.00-fold). By 2021, global HF prevalence reached 7048.1 thousand (5968.4, 8317.3). Males consistently demonstrated higher HF burdens than females across all World Health Organization (WHO) regions. Ischaemi...