Gut Microbiota‐Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High‐Altitude

作者：Yongqiang Zhou, Zhexin Ni, Jingjing Liu, Dezhi Sun, Pan Shen, Xi Chen, Gaofu Li, Zhijie Bai, Yangyi Hu, Ningning Wang, Rui Wang, Le Luo Guan, Yihao Wang, Xianglin Tang, Yungang Lu, Baokun He, Haitao Lu, Wei Zhou, Yue Gao · 发表于：Exploration · 年份：2025 · DOI：10.1002/exp.20240332 · 被引用次数：10 · 研究领域：Gut microbiota and health、Diet and metabolism studies、Metabolomics and Mass Spectrometry Studies

ABSTRACT Young migrants, particularly those at high altitudes, are predisposed to heart health abnormalities, including high‐altitude heart disease. Despite the profound impact of hypobaric hypoxia on the gut microbial community, the understanding of the roles played by gut microbiota and gut microbiota‐associated serum metabolites in high‐altitude heart diseases remains limited. Therefore, we conducted a comprehensive multi‐omics analysis involving 230 graduates from the same university, with 163 Tibetan Plateau migrants and 67 Chengdu Plain residents, and identified 206 differential metabolites (82 in serum and 124 in feces) and 369 species that differed between migrants and residents. Among these, 27 microbial species and four metabolites (Ketoglutaric acid, L‐Aspartic acid, 3‐Guanidinopropionic acid, betaine) detected in both serum and feces were found to be associated with migrants exhibiting compromised heart health, as diagnosed through clinical examinations. Notably, the abundances of Veillonella rogosae and Streptococcus rubneri were correlated with serum levels of L‐Aspartic acid, betaine, and Ketoglutaric acid in heart health‐abnormal individuals. Validation of these microbiome biomarkers and gut microbiota‐associated serum metabolites in an independent cohort demonstrated their excellent predictive ability for indicating heart health abnormalities in migrants (AUC = 0.7857). Furthermore, supplementation with these identified species or gut microbiota‐associated se...