Exploring the role of gut microbiota in Parkinson’s disease: insights from fecal microbiota transplantation

作者：Mengqi Guo, Han Gao, Yuan Wang, Yuanyuan Xiang · 发表于：Frontiers in Neuroscience · 年份：2025 · DOI：10.3389/fnins.2025.1574512 · 被引用次数：10 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Dysphagia Assessment and Management、Gut microbiota and health

As a common neurodegenerative disease, Parkinson’s disease (PD) is typified by α -synuclein ( α -syn) aggregation and progressive degeneration of dopaminergic neurons within the substantia nigra. Clinical manifestations encompass motor symptoms and non-motor aspects that severely impair quality of life. Existing treatments mainly address symptoms, with no effective disease-modifying therapies available. The gut microbiota refers to the community of microorganisms that colonize the intestinal tract. The gut microbiota, gut, and brain are all connected via a complicated, mutual communication pathway known as the “gut microbiota-gut-brain axis.” Gut microbiota dysbiosis is strongly linked to the onset and course of PD, according to growing data. In individuals with PD, gut dysbiosis correlates with clinical phenotype, disease duration, severity, and progression rates. Mechanistically, gut dysbiosis contributes to PD through enhanced intestinal permeability, increased intestinal inflammation and neuroinflammation, abnormal α -syn aggregation, oxidative stress, and reduced neurotransmitter synthesis. Therefore, focusing on the gut microbiota is regarded as a potentially effective treatment strategy. Fecal microbiota transplantation (FMT) is an emerging approach to modulate gut microbiota, with the goal of recovering microbiota diversity and function by transferring functional intestinal flora from healthy individuals into patients’ gastrointestinal tracts. FMT is expected to becom...