Biomimetic Synthesis of Myrtucommulones D–E

作者：Hong Guo, Ming-Fang Qi, Sisi Wang, Y. F. Zhu, Shi-Lin Lin, Meiqi Zheng, Yan-Yi Wu, Yanxia Hu, Chuang‐Chuang Li, Lei Wang, Min-Jing Cheng, Wen‐Cai Ye · 发表于：The Journal of Organic Chemistry · 年份：2025 · DOI：10.1021/acs.joc.5c00859 · 被引用次数：4 · 研究领域：Synthesis of Organic Compounds、Axial and Atropisomeric Chirality Synthesis、Synthesis and Biological Activity

A concise and efficient biomimetic synthesis of myrtucommulones D-E has been achieved, proceeding in just 6-7 linear steps from readily available biogenetic building blocks. The key feature of the synthesis was the Zn-mediated skeletal rearrangement reaction, without the need for rare metal photocatalysts and visible light. Based on this biomimetic synthesis, four compounds demonstrated moderate to excellent cytotoxic activities against osteosarcoma cells (U2OS and 143B).