Abstract 1654 Chronic Stress Promotes Melanoma Progression Through Upregulation of MIF in the Tumor Microenvironment

作者：Kerun Cao, Trang Hoang, D. J. Lam, Pedro López, Guadalupe Rodríguez, Kati Phan, Rebecca Rosero, Jerry Amomoy, Gabriel J. Villares · 发表于：Journal of Biological Chemistry · 年份：2025 · DOI：10.1016/j.jbc.2025.108670 · 研究领域：Macrophage Migration Inhibitory Factor、Nuclear Receptors and Signaling

Previous studies have shown that stress plays a role in tumor growth and metastasis in some cancers including ovarian cancer. Stress induces the release of catecholamines, like norepinephrine (NE), throughout the body which binds to the beta-3 adrenergic receptors of cancer cells and tumor-associated-macrophages (TAMs) in the tumor microenvironment (TME), which plays an important role in cancer progression. Our research investigates our hypothesis that NE stimulates TAMs in the TME to release pro-inflammatory cytokines which aid tumor growth, angiogenesis, invasion, and metastasis-specifically in melanoma.