Emodin Inhibits NLRP3 Inflammasome Activation and Protects Against Sepsis via Promoting FUNDC1-Mediated Mitophagy

作者：Wei Fu, Shu-Chang Liu, Tongtong Xu, Ying Liu, Teng Zhang, Dongjie Liu, Xiao Wang, Jianyao Wang, Yuxin He, Tao Ma · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.110904 · 被引用次数：22 · 研究领域：Optimism, Hope, and Well-being

, emodin confers significant protection in sepsis models, with these protective effects being lost in NLRP3-deficient mice or upon macrophage-specific deletion of FUNDC1. Collectively, our findings uncover a novel CK2-FUNDC1-mitophagy axis through which emodin inhibits NLRP3 inflammasome activation, highlighting its promise as a clinically translatable candidate for the treatment of NLRP3-driven inflammatory diseases.