Nucleus Basalis of Meynert as a DBS target

作者：Ekaterina Levichkina, Trichur R. Vidyasagar, Chris French · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2025 · DOI：10.1101/2025.06.11.659014 · 被引用次数：1 · 研究领域：Neuroscience and Neuropharmacology Research、Neurogenesis and neuroplasticity mechanisms、Neurological disorders and treatments

Abstract Several clinical attempts to use deep brain stimulation applied to nucleus basalis of Meynert to reduce cognitive decline in different types of dementia report inconclusive effects. At the same time, experiments in rodents have largely demonstrated cognitive improvement. The hypothesised basis for this difference was the application of different patterns of stimulation – tonic continuous over multiple sleep-wake cycles in human clinical trials vs intermittent bursts over shorter intervals in animal studies. However, since no systematic testing of the effects of different stimulation patterns applied in different states of vigilance was conducted, it remains unclear what specific attributes of cortical responses are associated with these patterns, and the effect of vigilance state on pattern response. We hypothesised that communication between nucleus basalis and its cortical targets involves frequencies in both low and high ranges, making burst-type intermittent patterns potentially more effective. Therefore we studied preferred frequencies of neuronal synchronization within nucleus basalis as well as between nucleus basalis and its cortical targets in B6 mouse strain (N=9, age 4-6 month) by recording neuronal spiking and local field potentials (LFP) from 2 sites of the nucleus basalis and 4 cortical sites simultaneously across multiple sleep-wake cycles. Spike-field coherence (SFC) analysis revealed natural synchronization tendencies of nucleus basalis – all animals...