Phenotypes of Atopic Dermatitis and Development of Allergic Diseases

作者：Alexandra R. Sitarik, Amy Eapen, Jocelyn M. Biagini Myers, Daniel J. Jackson, Christine L.M. Joseph, Haejin Kim, Lisa J. Martin, Katherine Rivera-Spoljaric, Eric Schauberger, Ganesa Wegienka, Casper G. Bendixsen, Agustin Calatroni, Soma Datta, Diane R. Gold, Lisa Gress, Tina V. Hartert, Christine C. Johnson, Gurjit K. Khurana Hershey, Fernando D. Martinez, Rachel L. Miller, Christine M. Seroogy, Sweta Singh, Anne L. Wright, James E. Gern, Anne Marie Singh, ECHO Children’s Respiratory and Environmental Workgroup, Leonard B. Bacharier, Paloma I. Beamer, Dean Billheimer, Alex Binder, Gordon R. Bloomberg, Yury A. Bochkov, Steven M. Brunwasser, Tara F. Carr, Teresa M. Chipps, Gina Crisafi, Suman R. Das, Brent Davidson, William D. Dupont, Abby Engelhart, Samantha Fye, Ronald E. Gangnon, Tebeb Gebretsadik, Brian Hallmark, Marilyn Halonen, Julie Herbstman, Molly Johnson, Meyer Kattan, Matthew Keifer, Carin Lamm, Kristine Lee, Robert F. Lemanske, Grace K. LeMasters, Stephanie Lovinsky‐Desir, Jomol Matthew, Christopher G. McKennan, Wayne J. Morgan, Mariné Nalbandyan, George O'connor, Irene M. Ong, R. Stokes Peebles, Frederica Perera, Matthew S. Perzanowski, Chris M Reyes, Christian Rosas‐Salazar, Patrick Ryan, Hugh A. Sampson, Megan Sandel, Ruchika Sangani, Meghan H. Shilts, Akihiro Shiroshita, Brittney M. Snyder, Ronald L. Sorkness, Rhoda Sperling, Jeff Stokes, Zheng-Zheng Tang, Kedir N. Turi, Jeffrey J. VanWormer, Cynthia M. Visness, Robert A. Wood, Rosalind J. Wright, Melissa Yaeger, Edward M. Zoratti · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.15094 · 被引用次数：12 · 研究领域：Dermatology and Skin Diseases、Food Allergy and Anaphylaxis Research、Asthma and respiratory diseases

Importance: Atopic dermatitis (AD) is the most common inflammatory disease in childhood, and children with AD are more likely to develop other allergic diseases, including food allergy, allergic rhinitis, and asthma. Objective: To determine the phenotypes of AD expression across 12 US birth cohorts and identify factors associated with phenotype and development of allergic diseases. Design, Setting, and Participants: This cohort study compiled longitudinal data from 12 observational US birth cohorts across decades (children born from April 1980 to June 2019) in the Environmental Influences on Child Health Outcomes (ECHO) Children's Respiratory and Environmental Workgroup with follow-up to September 2022. Participants were enrolled prenatally; children with 3 or more AD assessments across the first 84 months of life were included in analyses. Data were analyzed from December 2020 to April 2024. Exposures: Exposures included decade of birth, cohort type (population-based or high-risk), family history of asthma (mother, father, or sibling), birth order, gestational age at birth, delivery mode, breastfeeding, pet exposure, antibiotic use, environmental tobacco smoke exposure, allergic sensitization, peripheral blood eosinophil count, and total IgE. Main Outcomes and Measures: Primary outcomes were AD phenotype, food allergy, allergic rhinitis, asthma, and wheeze. Longitudinal latent class analysis was used to identify underlying longitudinal patterns of AD expression, and associat...