Efficient Synthesis of Anticoagulant Fondaparinux via Orthogonal One‐Pot Glycosylation and Microwave‐Assisted Simultaneous O,N‐Sulfonation

作者：Qingqing Shi, Pengchao Liu, Biao Yu, Peng Xu · 发表于：Chinese Journal of Chemistry · 年份：2025 · DOI：10.1002/cjoc.70116 · 被引用次数：5 · 研究领域：Carbohydrate Chemistry and Synthesis、Synthesis and Biological Activity、Chemical Synthesis and Analysis

Comprehensive Summary Here, we report an effective approach to the synthesis of anticoagulant fondaparinux, utilizing orthogonal one‐pot [1+2+2] glycosylation, simultaneous O , N ‐sulfation and global debenzylation at atmospheric pressure as key steps. The synthetic route was achieved through the longest linear sequence of 12 steps with 19% overall yield from a commercially available disaccharide. The present synthetic route remarkably enhances synthetic efficiency and streamlines the purification process, thereby opening up a new avenue for the large‐scale synthesis of fondaparinux and relevant heparin fragments.