Cerebellar–Basal Ganglia Dysconnectivity in Schizophrenia: Insights into Motivational Deficits

作者：Xuan Wang, Xiaodong Guo, Xin‐lu Cai, Bingjie Huang, Yi Wang, Chengcheng Pu, Xin Yu, Simon S. Y. Lui, Raymond C. K. Chan · 发表于：Schizophrenia Bulletin · 年份：2025 · DOI：10.1093/schbul/sbaf087 · 被引用次数：3 · 研究领域：Functional Brain Connectivity Studies、Neural dynamics and brain function、Neurotransmitter Receptor Influence on Behavior

BACKGROUND AND HYPOTHESIS: Motivational deficits are core negative symptoms of schizophrenia (SCZ), which have been linked to disruptions in reward network. Recent evidence suggests the cerebellum's role in motivational and hedonic processing. This study examined its connectivity with the reward network in SCZ and hypothesized that decreased connectivity would be found in SCZ patients and correlated with severe negative symptoms. STUDY DESIGN: This study employed a cross-sample validation approach using 2 independent cohorts (Sample 1: NSCZ = 62, NHC = 61; Sample 2: NSCZ = 53, NHC = 55). Resting-state functional connectivity was assessed using network-based analysis to identify disrupted subnetworks, followed by seed-based connectivity analysis to localize specific connections. Effective connectivity was assessed using spectral Dynamic Causal Modeling (DCM) for inferring the directional influences of abnormal connectivity related to amotivation or anhedonia. STUDY RESULTS: Network-based analysis in Sample 1 identified a disrupted subnetwork between the cerebellum (lobules VI, VIIb, VIII) and basal ganglia (putamen, caudate, pallidum) in SCZ, with cerebellar-pallidal connectivity associated with amotivation. Seed-based analysis in Sample 2 revealed reduced putamen/caudate-lobule VI connectivity, correlating with amotivation and anhedonia symptoms in SCZ. Spectral DCM indicated reduced excitatory input from cerebellum to the basal ganglia in Sample 1, but such results could not...