Global, regional, and national prevalence of prostate cancer from 1990 to 2021: a trend and health inequality analyses

作者：Xiaohu Zhao, Shuchen Liu, Zhihui Zou, Chang Yin Liang · 发表于：Frontiers in Public Health · 年份：2025 · DOI：10.3389/fpubh.2025.1595159 · 被引用次数：10 · 研究领域：Prostate Cancer Diagnosis and Treatment、Prostate Cancer Treatment and Research、Cancer survivorship and care

Background: Prostate cancer in men's health has become a significant driver of global disease burden, impacting aging populations worldwide. This study assesses its prevalence from 1990 to 2021 to reveal ongoing epidemiological trends and inform effective public health strategies. Methods: Prostate cancer prevalence estimates, including their 95% uncertainty intervals (UIs), were derived from the Global Burden of Disease (GBD) 2021 study. Then, temporal trends spanning the past 32 years were thoroughly analyzed using Joinpoint regression, with projections for the next 25 years made using the Bayesian Age-Period-Cohort (BAPC) model. Concurrently, disease trends were decomposed into components of population growth, aging, and epidemiological changes. Additionally, age-period-cohort (APC) models were also employed to explore the impact of age, time, and cohort effect on the relative risk of prostate cancer prevalence. And the cross-country inequalities in the prevalence of prostate cancer burden were meticulously evaluated through the Socio-Demographic Index (SDI), revealing significant disparities across socio-economic strata. Result: In 2021, over 10 million prostate cancer cases were recorded worldwide-a 188.85% increase from 3.6 million in 1990. The age-standardized prevalence rate (ASPR) rose at an estimated annual percentage change of 0.64% (95% UI: 0.47%-0.82%); Joinpoint regression revealed a steady increase in case numbers over 32 years, while the ASPR peaked and then s...