Associations between Aβ deposition and neurometabolic alterations in Alzheimer's disease: Insights from hybrid 3D MRSI‐PET imaging

作者：Miao Zhang, Jialin Hu, Yaoyu Zhang, Ziyu Meng, Yibo Zhao, Yudu Li, Yudu Li, Wen Jin, Xiaohang Qian, Lijun Wang, Guanyu Ye, Xufeng Jiang, Yadong Li, Yadong Li, Jian Ye, Huidong Tang, Jun Liu, Parashkev Nachev, Zhi‐Pei Liang, Biao Li, Yao Li, Yao Li · 发表于：Alzheimer s & Dementia · 年份：2025 · DOI：10.1002/alz.70332 · 被引用次数：3 · 研究领域：Advanced MRI Techniques and Applications、Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments

INTRODUCTION: Understanding the neurometabolic changes associated with amyloid-β (Aβ) deposition is important for early Alzheimer's disease (AD) diagnosis, but their spatial relationships remained unexplored due to technical limitations. METHODS: resolution) and Aβ-positron emission tomography (Aβ-PET) imaging. N-acetylaspartate, myo-inositol, and creatine maps were obtained from 174 participants: 39 controls, 65 mild cognitive impairment (MCI), and 70 AD patients. RESULTS: N-Acetylaspartate levels were negatively correlated with Aβ, while myo-inositol levels were positively correlated globally. Regional associations with Aβ include N-acetylaspartate reductions in frontal cortex, anterior cingulate cortex, and precuneus, and myo-inositol increases in precuneus, lateral temporal, and lateral parietal cortices. Combined MRSI and PET biomarkers achieved the highest diagnostic accuracy for MCI and AD . DISCUSSION: Hybrid high-resolution 3D MRSI and Aβ-PET imaging provides valuable insights into Aβ's impact on neurometabolic changes, improving early AD diagnosis. HIGHLIGHTS: Hybrid 3D magnetic resonance spectroscopic imaging-positron emission tomography (MRSI-PET) imaging reveals Aβ deposition impact on neurometabolism in Alzheimer's disease (AD). N-acetylaspartate (NAA) as a neuronal metabolic marker is negatively associated with Aβ globally and locally. Myo-inositol (mI) as a glial metabolic marker is positively associated with Aβ globally and locally. Combining 3D magnetic reso...