Magnetic stimulation delivered through an aligned nanofibrous scaffold composed of magnetic graphene hybrids promotes optic nerve regeneration

作者：Lu Yan, Yuexiang Liang, Dong Chen, Robert Z. Qi, Xiaohua Chen, He Ma, Lin Yao, Tom Lawson, Changchun Yu, Wenjing Zhang, Yong Liu · 发表于：Cell Reports Physical Science · 年份：2025 · DOI：10.1016/j.xcrp.2025.102647 · 被引用次数：2 · 研究领域：Graphene and Nanomaterials Applications、Photoreceptor and optogenetics research、Neuroscience and Neural Engineering

Optic nerve damage and the resulting permanent vision loss presents a significant challenge in ophthalmology. This injury is primarily caused by the progressive degeneration and loss of retinal ganglion cells (RGCs). This work reports an innovative approach using aligned magnetic stimulation (MS) to promote optic nerve regeneration and restore partial function. We developed an aligned magnetic nanofibrous scaffold (AMNS) formed from magnetic graphene hybrids. The AMNS is constructed with a core of coaxially electrospun magnetic graphene hybrids packaged in a shell of poly(lactic-co-glycolic) acid (PLGA) copolymer. In vitro experiments revealed that aligned MS sharply improves the directional extension of RGC neurites by more than 60%. Furthermore, in vivo results further support the claim that aligned MS significantly restores optic nerve function, relieves optic neurotrophy, and inhibits RGC apoptosis. This innovation has the potential to change future therapies for permanent vision impairments caused by optic nerve injury.