OTUD1 inhibits osteoclast differentiation and osteoclastic bone loss through deubiquitinating and stabilizing PRDX1

作者：Xiaoyu Sun, Tong Wu, Shuhong Chen, Zheyu Zhao, Ru Jia, Jun Ma, Lei Yin, Xingbei Pan, Yifan Ping, Yixin Mao, Lulu Ma, Yilin Ma, Wu Luo, Shengbin Huang, Guang Liang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.111360 · 被引用次数：7 · 研究领域：Ubiquitin and proteasome pathways、Cancer, Hypoxia, and Metabolism、ATP Synthase and ATPases Research

Our findings provided the first evidence that OTUD1 suppressed osteoclastogenesis by deubiquitinating PRDX1 and maintaining its stability, thereby offering a promising therapeutic approach for osteoclast-dependent bone diseases.