Identification of a Novel Small Molecule STING Agonist Reshaping the Immunomicroenvironment of Pancreatic Ductal Adenocarcinoma

作者：Pengyi Liu, Minmin Shi, Yang Liu, Yihao Liu, Jiayu Lin, Shuyu Zhai, Yizhi Cao, Dongjie Chen, Yongsheng Jiang, Chenghong Peng, Lei Zhang, Chunyong Ding, Lingxi Jiang, Baiyong Shen · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.107837 · 被引用次数：7 · 研究领域：interferon and immune responses、Ubiquitin and proteasome pathways、Neuroblastoma Research and Treatments

D166 is a novel and stable STING agonist that inhibits pancreatic tumor progression by activating the cGAS-STING pathway and remodeling the tumor immune microenvironment. Its combination with anti-PD-1 antibodies offers a promising strategy for overcoming the immunosuppressive barriers in pancreatic cancer, providing new therapeutic insights and directions.