Repurposing methimazole to promote coronary collateral circulation through MAPK1-mediated macrophage polarization via ferroptosis

作者：Ling-ping Zhu, Wei He, Ke-chuan Lin, Dan Wang, Linlin Wang, Shuai Li, Meilian Yao, Jing Chen, Meifang Chen, Guogang Zhang, Chuanchang Li, Ling-ping Zhu, Yongping Bai · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.111606 · 被引用次数：4 · 研究领域：Ferroptosis and cancer prognosis、Circular RNAs in diseases、RNA modifications and cancer

: This study reveals a novel therapeutic role for MMI in promoting CCC formation following MI through the modulation of macrophage polarization via the MAPK1/ROS axis-mediated inhibition of ferroptosis. These findings highlight the potential of MMI as a strategy for enhancing cardiac repair and advancing collateral circulation therapies for ischemic heart disease.