Boosting mRNA cancer vaccine efficacy via targeting Irg1 on macrophages in lymph nodes

作者：Wenwen Wei, Xiao Yang, Yeshan Chen, Mengjie Che, Ying Ye, Yue Deng, Mengyao Su, Yajie Sun, Jingshu Meng, Yan Hu, Jiacheng Wang, Yijun Wang, Zishan Feng, Zhiyuan Zhou, Yan Li, Qian Li, Zhanjie Zhang, Bian Wu, Haibo Zhang, You Qin, Lu Wen, Chao Wan, Kunyu Yang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.110305 · 被引用次数：7 · 研究领域：Cancer Immunotherapy and Biomarkers、RNA modifications and cancer、Immunotherapy and Immune Responses

siRNA-LNP could be a promising strategy to improve the therapeutic efficacy of mRNA cancer vaccines.