Endothelium-specific sensing of mechanical signals drives epidermal aging through coordinating retinoid metabolism

作者：Xia Wu, Jiangming Zhong, Jingwei Jiang, Yi Zou, Dehuan Wang, Ziyan Chen, Mengyue Wang, Xinyu Shen, Zeming Li, Xiao Yang, Yong Yi, Fangqi Tang, Xiaoyu Long, Weiming Qiu, Qu Tang, Xiao Xiang, Xun Zhou, Mingxing Lei, Peng Shu, Qiang Zhou · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.112299 · 被引用次数：6 · 研究领域：Retinoids in leukemia and cellular processes

These findings highlight the intricate intercellular dynamics that underlie skin aging and shed light on the previously underexplored role of mechano-sensitive endothelial cells in this process. Aging as an endothelial-specific coordination failure with other cells in the skin and potentiates developing combinatorial mechano-metabolic intervention strategies to restore tissue-level rejuvenation.