Inflammation-associated Lipidomic Signatures Prior to Carotid Artery Atherosclerosis in People Living With HIV

作者：Yingying Ding, Xiaoxiao Chen, Weiwei Shen, Hao Yin, Yunqiu Zhang, Cheng Feng, Jiayu He, Miaochen Wang, Jingjing Xia, Haijiang Lin, Na He · 发表于：The Journal of Clinical Endocrinology & Metabolism · 年份：2025 · DOI：10.1210/clinem/dgaf331 · 被引用次数：2 · 研究领域：HIV-related health complications and treatments、HIV Research and Treatment、Diabetes, Cardiovascular Risks, and Lipoproteins

OBJECTIVES: Lipid metabolism plays an important role in HIV-associated atherosclerosis. However, the interplay between lipid metabolism, uncontrolled inflammation, and subclinical carotid atherosclerosis (SCA) in HIV infection remains poorly understood. This study aimed to characterize lipidome signatures that, together with inflammatory patterns, may predispose HIV-positive individuals to incident SCA. METHODS: A nested case-control study was conducted within the Comparative HIV and Aging Research Cohort in Taizhou, China, including 115 HIV-positive individuals with incident SCA, 112 age- and sex-comparable HIV-positive normal controls, and 117 HIV-negative normal controls. Untargeted lipidomic profiling and inflammatory marker assessments were performed at baseline and follow-up. A total of 649 plasma lipid species were annotated, and 20 plasma inflammatory markers were quantified. RESULTS: Three distinct baseline lipidomic signatures were identified: 1 upregulated in HIV infection, 1 downregulated, and 1 upregulated in HIV-associated SCA (showing a decreasing or increasing trend from HIV-negative normal controls to HIV-positive normal controls to SCA cases). The latter 2 signatures were enriched in glycerophospholipid metabolism, particularly involving lysophospholipids and short-chain fatty acyls. Lipid species within each signature exhibited distinct correlation patterns with subsets of inflammatory proteins, a pattern that persisted after the onset of SCA. Network analy...