An antibacterial hydrogel coating with pH-regulated rifampicin loading for prevention of catheter-associated infections

作者：Jia-yin You, Jiarong Wang, Zhaoyang Chen, Yangxiu Mu, Yi-Jing Yin, Xing‐Wang Wang, Ke‐feng Ren, Jian Ji · 发表于：Journal of Materials Chemistry B · 年份：2025 · DOI：10.1039/d5tb00520e · 被引用次数：3 · 研究领域：Central Venous Catheters and Hemodialysis、Intramuscular injections and effects、Intraocular Surgery and Lenses

) across a pH range of 2.0-9.5 due to pH-dependent charge modulation. Additionally, the sulfonated polyelectrolyte simultaneously offered excellent hydrophilic lubricity with a coefficient of friction <0.03 and anticoagulant properties. Such a multifunctional hydrogel coating with antibacterial, lubricating, and anticoagulant properties provides a promising approach to reducing catheter-associated infections, equipping medical polymer-based catheters with better practical performance.