Dual regulation of the cGAS-STING pathway: new targets and challenges for subtype-specific immunotherapy in breast cancer

作者：Hanchu Xiong, Rongxue Li, Lixian Yang, Yucheng Li, Xiao Ma · 发表于：Frontiers in Oncology · 年份：2025 · DOI：10.3389/fonc.2025.1619097 · 被引用次数：5 · 研究领域：interferon and immune responses、Ubiquitin and proteasome pathways、RNA modifications and cancer

Research on immune regulation mechanisms in breast cancer is crucial for breaking through therapeutic bottlenecks. This paper comprehensively reviews the dual roles of the cGAS-STING pathway in Luminal, HER2+, and triple-negative breast cancer (TNBC): its activation can enhance antitumor immunity, but chronic activation may lead to immunosuppression. By integrating molecular mechanisms, clinical translation, and subtype-specific strategies, it provides new directions for precision immunotherapy.