Challenges and strategies for spinal cord injury research recruitment in rehabilitation hospitals: a single center perspective

作者：Steven Kirshblum, Brittany Snider, Einat Engel‐Haber · 发表于：Spinal Cord · 年份：2025 · DOI：10.1038/s41393-025-01094-w · 被引用次数：3 · 研究领域：Spinal Cord Injury Research、Traumatic Brain Injury Research、Ethics in Clinical Research

STUDY DESIGN: A narrative review and perspective based on the experience of a single site in the U.S recruiting participants for clinical trials during the subacute phase (2 weeks to 3 months) following a traumatic spinal cord injury (SCI). OBJECTIVES: To discuss challenges and propose strategies for enrolling individuals with SCI in research during the subacute phase within a comprehensive inpatient rehabilitation program. SETTING: Acute rehabilitation hospitals where patients with SCI typically spend part of the subacute post-injury period. METHODS: This review draws on the authors' experience in research recruitment and retention. Key barriers and potential solutions are explored from both a practical and conceptual standpoint. RESULTS: Challenges identified include heterogeneous impairments, older age, higher incidence of incomplete injuries, placement issues, competition among studies, limited patient volume, tight rehabilitation schedules, logistical and medical concerns, and misalignment of research measures with clinical practices. Based on experience and literature review, strategic planning including integration of individuals with lived experience into the study design team, patient education, simplified consent processes, flexible research protocols, collaboration between clinical and research teams, and patient-centered approaches can enhance recruitment efforts. CONCLUSIONS: Research recruitment during the subacute phase of SCI presents numerous medical, injury-...