“Dual lock-and-key” triggered and endoplasmic reticulum targeting nanophotosensitizers for activatable Type-I photodynamic and photothermal therapies

作者：Rumeng Zhan, Wei Zhou, Hongyu Ma, Menghui Zou, Mingming Zhang, Weian Zhang, Jia Tian · 发表于：Chemical Science · 年份：2025 · DOI：10.1039/d5sc01987g · 被引用次数：10 · 研究领域：Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies、Advanced Nanomaterials in Catalysis

investigations demonstrated that the TME dual triggered activatable nanophotosensitizer, upon NIR laser irradiation, effectively kills tumor cells, and significantly suppresses tumor growth through fluorescence imaging-guided Type-I PDT and PTT. This work provides a pathway for developing TME-triggered precise phototherapeutics with improved biosafety and potential for clinical translation.