Active Travel Mode and Incident Dementia and Brain Structure

作者：Chuan Hou, Yaqi Zhang, Feiyang Zhao, Yanling Lv, Mengyun Luo, Chensheng Pan, Ding Ding, Liangkai Chen · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.14316 · 被引用次数：8 · 研究领域：Older Adults Driving Studies、Urban Transport and Accessibility、Transportation Planning and Optimization

Importance: Active travel modes, such as walking and cycling, are feasible and readily embraced forms of physical activity, but their association with dementia risk and brain structure remains unclear. Objectives: To investigate the long-term association between travel modes and dementia risk and brain structural metrics and to evaluate whether genetic predisposition could modify the association between travel modes and dementia risk. Design, Setting, and Participants: This prospective cohort study included data collected from the UK Biobank from March 13, 2006, to October 1, 2010. Data were analyzed from March to October 2024. Exposures: Travel modes assessed using the question "In the last 4 weeks, which forms of transport have you used most often to get about (not including any journeys to and from work)?" and categorized into 4 groups: nonactive, walking, mixed-walking, and cycling and mixed-cycling mode. Main Outcomes and Measures: The incidence of all-cause dementia (including young-onset dementia [YOD] and late-onset dementia [LOD]) was the primary outcome, and dementia subtypes, such as Alzheimer disease (AD) and brain structure, were the secondary outcomes; all were identified through hospital records and death registers. Brain structure was measured by a magnetic resonance imaging scan. Travel mode and risk of incident dementia were assessed using Cox proportional hazards regression models with hazard ratios and 95% CIs. Results: The study encompassed 479 723 partic...