Helicobacter pylori infection, anti-Helicobacter pylori treatment and risk of colorectal cancer and adenoma: an observational study and a meta-analysis

作者：Xue Li, Huan-Qing Tao, Ji-Er Zhao, Juan Zhu, Lingbin Du, Markus Gerhard, Wenqing Li · 发表于：EClinicalMedicine · 年份：2025 · DOI：10.1016/j.eclinm.2025.103299 · 被引用次数：20 · 研究领域：Helicobacter pylori-related gastroenterology studies、Colorectal Cancer Treatments and Studies、Gastric Cancer Management and Outcomes

Background Recent studies suggest a possible link between Helicobacter pylori (H. pylori) infection and risk of colorectal cancer. We examined the association between H. pylori infection, anti- H. pylori treatment, and colorectal cancer and its precursor, adenoma, based on an observational study and a meta-analysis. Methods The observational study part included 3475 participants undergoing colonoscopy and H. pylori testing within the framework of a screening program in Zhejiang Province, China between March 8 and December 29, 2023. Logistic regression models were used to analyze the associations between H. pylori infection and the risk of colorectal cancer and adenoma. Additionally, a meta-analysis was conducted on the associations of H. pylori infection, anti- H. pylori treatment and risk of colorectal cancer and adenoma. Three databases (PubMed, Embase, and Cochrane Library) were searched for relevant studies from inception up to April 9, 2025. Two reviewers independently screened records for eligibility, extracted summary-level data and assessed study quality. Random-effects models were used to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs). Study quality was evaluated using the Newcastle–Ottawa Scale for case–control and cohort studies, and adhering to the Agency for Healthcare Research and Quality's recommendations for cross-sectional studies. Heterogeneity was quantified using I 2 statistics and subgroup analyses were conducted to identify pot...