Efficacy and safety of a traditional Chinese herbal formula Xuefu Zhuyu prescription for hypertension: A meta-analysis of randomized controlled trials

作者：Yunxiao Zhang, Dong Guo, Hongshuo Shi, Wenwen Li, Jiaqi Fu, Shudi Li, Huidan Xie, Shouqiang Chen · 发表于：Medicine · 年份：2025 · DOI：10.1097/md.0000000000041661 · 被引用次数：1 · 研究领域：Blood Pressure and Hypertension Studies、Neurological Disease Mechanisms and Treatments、Traditional Chinese Medicine Analysis

BACKGROUND: Hypertension is a major risk factor for cardiovascular disease, kidney disease, and stroke. Xuefu Zhuyu decoction (Xuefu Zhuyu prescription [XZP]) is a classic Chinese medicine prescription, which has been widely used in headache, vertigo, hypertension, and so on. This meta-analysis aimed at evaluating the efficacy and safety of XZP for hypertension and related risk diseases of hypertension, especially cardiovascular disease, with sufficient evidence. METHODS: A comprehensive literature search was performed in 7 electronic databases from their establishment up to April 7, 2022, to examine the therapeutic effect and safety of XZP for hypertension. The primary outcome included systolic blood pressure (BP), diastolic BP, categorical BP, traditional Chinese medicine syndrome integral, and traditional Chinese medicine syndrome effect. The secondary outcomes were defined as vascular endothelial function, ventricular remodeling, and blood lipids. Poor prognosis included stroke, heart failure, and so on. Continuous variables were analyzed using mean difference and 95% confidence intervals. Relative risk and 95% confidence interval were used for dichotomous data. The data were pooled and analyzed by RevMan5.4. RESULTS: A total of 37 studies with 3391 hypertensive patients were included for meta-analysis. All studies compared XZP and antihypertensive or lipid-lowering drugs with conventional treatment used alone. Overall, 25 studies demonstrated that XZP substantially reduc...