Antitumor/anti-inflammatory effects/tissue healing as an all-in-one therapeutic strategy for nasopharyngeal carcinoma

作者：Ni Fan, Haitao Lv, Liting Lin, Yiqun Zhang, Yang Qiao, Xiaopei Zhang, Zengyang Li, Xianwen Wang, Xingliang Dai, Jun Dong · 发表于：Journal of Nanobiotechnology · 年份：2025 · DOI：10.1186/s12951-025-03520-w · 被引用次数：11 · 研究领域：Immune cells in cancer、Nanoplatforms for cancer theranostics、Cancer Research and Treatments

Nasopharyngeal carcinoma (NPC) is one of the most prevalent cancers in the head and neck region. The development of innovative therapies that are effective at eliminating tumors while minimizing damage to surrounding normal tissues due to postoperative complications is crucial. To solve this problem, a gelatin-sodium alginate (Gel-SA) hydrogel containing bismuth selenide nanosheets (Bi2Se3 NSs) has been developed, which introduces a “switch” of near-infrared (NIR) light for photodynamic therapy (PDT) and photothermal therapy (PTT) to significantly increase the level of oxidative stress while inducing ferroptosis and apoptosis to synergistically treat tumors. Once the treatment of the tumor has been completed, NSs remove a large number of free radicals left by NIR irradiation because of their excellent anti-inflammatory performance and combine with the rich nutrients in Gel-SA to protect and repair the tissues around the tumor. Combining Bi2Se3 NSs and Gel-SA is an effective solution for treating NPC, as it ablates tumors while protecting surrounding tissues.