Trajectories of Chemsex Engagement Across Time Among PrEP-Using Men Who Have Sex with Men: Results from the French ANRS-Prévenir Cohort

作者：Emīls Sietiņš, Luis Sagaon‐Teyssier, Adbourahmane Sow, Lambert Assoumou, Marion Mora, Lydie Béniguel, Daniela Rojas Castro, David Michels, Juan Camilo Jones, Jade Ghosn, Dominique Costagliola, Bruno Spire, Perrine Roux, Jean‐Michel Molina, Christel Protière · 发表于：International Journal of Sexual Health · 年份：2025 · DOI：10.1080/19317611.2025.2511902 · 被引用次数：3 · 研究领域：HIV/AIDS Research and Interventions、HIV/AIDS drug development and treatment、HIV Research and Treatment

Objectives To identify trajectories of chemsex engagement and their evolution across time among men who have sex with men (MSM) and the associated factors.Methods Among 2518 PrEP-using MSM in the French ANRS- Prévenir cohort, a group-based trajectory model was used to identify trajectories of chemsex engagement. A multivariable model was then used to estimate time-constant factors associated with trajectory membership, and time-varying factors associated with the shape of each trajectory. Data were collected quarterly from self-administered online questionnaires and electronic case record forms. The median follow-up time was 21 months [interquartile range: 9-27 months].Results Four distinct trajectories were identified: the Null/low (probability of engagement) (N-CX, n = 1881, 75%), the Increasing (I-CX, n = 158, 6%), the Decreasing (D-CX, n = 195, 8%), and the High (H-CX, n = 284, 11%). Compared to N-CX: MSM in the I-CX and D-CX were younger (OR [95%CI]: 0.95[0.93–0.98], p < 0.001 & 0.94[0.91–0.96] p < 0.001 per additional year or point (p/y), respectively), while MSM in the H-CX were older (1.03[1.01–1.05] p/y, p = 0.016); depression score was higher among the D-CX (1.02[1.00–1.04] p/y, p = 0.026) and lower among the I-CX (0.97[0.94–0.99] p/y, p = 0.028). Use of daily PrEP regimen (compared to ‘on-demand’) was associated with increased and decreased likelihood of chemsex engagement for the H-CX (Coeff.(SE): 0.75(0.33), p = 0.027) and D-CX (−0.41(0.20), p = 0.043), respectiv...