Synthesis of SeCF 3 -Substituted Oxazines and Oxazolines through Electrophilic Trifluoromethylselenolation Cyclization of Propargylic Amides

作者：Jia Wang, Jiaqi Niu, Jiacheng Li, Lixia Liu, Xuefang Shang, P. Zhou, Shujun Chao · 发表于：The Journal of Organic Chemistry · 年份：2025 · DOI：10.1021/acs.joc.5c00930 · 被引用次数：7 · 研究领域：Fluorine in Organic Chemistry、Inorganic Fluorides and Related Compounds、Carbon dioxide utilization in catalysis

The electrophilic trifluoromethylselenolation cyclizations of propargylic amides are disclosed. The transformations undergo the 6- endo -dig and 5- exo -dig cyclizations to synthesize SeCF 3 -substituted oxazines and oxazolines, respectively, which are induced by N -trifluoromethylselenophthalimide. This protocol is suitable for late-stage applications of complex natural products and drug molecules.