Radiation-induced cardiac substructure damage and dose constraints: a review

作者：Xinyi Li, Yajing Wu, Qingyu Wang, B. Li, Jun Wang · 发表于：Radiation Oncology · 年份：2025 · DOI：10.1186/s13014-025-02668-x · 被引用次数：18 · 研究领域：Chemotherapy-induced cardiotoxicity and mitigation、Cardiac Imaging and Diagnostics、Effects of Radiation Exposure

The field of radiation-induced cardiac damage (RIHD) is garnering increasing attention. The application of advanced radiotherapy reduces the cardiac radiation dose. Still, challenges remain in the uneven dose distribution, the different sensitivity among cardiac substructures (CSs), and the delineation of target areas within these substructures. This article encompasses cardiac substructures, including atria and ventricles, coronary arteries, pulmonary vasculars and superior vena cava (SVC), cardiac conduction system, heart valves and heart base. This review will provide better understanding of RIHD as it firstly summarizes dose limitation of CSs, as well as the risk of cardiac toxicities and its impact on survival following the comprehensive search.